There are those who believe that anti-malware applications actually aren’t needed. While I disagree with that as an absolute statement, the fact is that if you really know what you’re doing – deeply – then it may be possible to be relatively safe on your own.
It’s just not something I advise, since it relies on being 100% right 100% of the time when it comes to identifying and avoiding potential threats. Things have become much too complex to rely on that kind of accuracy.
Not only do I advise running anti-malware tools, I run them myself.
The real problem is something else entirely.